Carlo Filippo Antonio Spinola y Colonna, 4th marquis of the Balbases, (Madrid, Spain, 11 November 1665 – after 30 July 1721) , Viceroy of Sicily, 1707–1713, during the European military conflict known as Spanish Succession War holding the kingdom of Sicily for pretender, after recognized as king of Spain, Philip V of Spain. He was 4th Duke of Sesto, a member since 1686 of the Military Order of Santiago, the son, out of 3 males/9 females siblings, of Paolo Spinola, 3rd Marquis of the Balbases, (Milan, Italy, 24 February 1628 -Madrid, Spain, 23 December 1699), Governor of the Duchy of Milan, 1668 - 1670.
His mother, Anna Colonna (1629–1686), was a daughter of Marcantonio V Colonna (son of Filippo I Colonna and sister of Anna Colonna-Barberini), who described himself as Prince of Paliano during the period 1639 - 1659. The Princedom title was held by Anna Colonna's brother, Lorenzo Onofrio Colonna during the period 1659 - 1689.
He married, Madrid, 20 September 1682, Isabel María de la Cerda y Aragón, (16677 - 1707), a daughter of Juan Francisco de la Cerda, 8th Duke of Medinaceli, (1637–1691) and Catalina de Aragón-Folch de Cardona, duchess of Cardona, duchess of Segorbe, duchess of Lerma, having 2 sons and 7 daughters, as well as three bastards, one male, 2 females.
The eldest son, 5th Duke of Sesto and 5th Marquis of the Balbases since 1721 was called Ambrosio Gaetano Spinola y de la Cerda, 5th Marquis of the Balbases, (Milan, Italy, 20 January 1696 - 1757), becoming a Knight of the Order of the Golden Fleece in 1737.